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儿童肾囊肿的罕见病因:Xp11.2易位性肾细胞癌。

A rare cause of childhood renal cysts: Xp11.2 translocation renal cell carcinoma.

作者信息

Taşkınlar Hakan, Avlan Dinçer, Çıtak Çağlar, Polat Ayşe, Naycı Ali

机构信息

Pediatric Surgery Department, Mersin University Hospital, Mersin, Turkey.

出版信息

Can Urol Assoc J. 2015 Jan-Feb;9(1-2):E36-8. doi: 10.5489/cuaj.2321.

DOI:10.5489/cuaj.2321
PMID:25624966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4301968/
Abstract

Pediatric renal cysts are rare, usually asymptomatic and incidentally detected in children. Cyst associated renal cell carcinoma (RCC) or cystic RCC is extremely rare in children. Bosniak classification system has been accepted for the management of cystic renal masses. Xp11.2 translocation RCC is a recently classified distinct subtype and usually affects children and adolescents. We report the case of a 10-year-old girl with Xp11.2 translocation RCC from a cyst of the right kidney.

摘要

小儿肾囊肿罕见,通常无症状,在儿童中多为偶然发现。囊肿相关性肾细胞癌(RCC)或囊性RCC在儿童中极为罕见。波斯尼亚克分类系统已被用于管理囊性肾肿块。Xp11.2易位性RCC是一种最近分类的独特亚型,通常影响儿童和青少年。我们报告了一名10岁女孩因右肾囊肿发生Xp11.2易位性RCC的病例。

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本文引用的文献

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Guidelines on the management of renal cyst disease.肾囊肿疾病管理指南。
Can Urol Assoc J. 2010 Apr;4(2):98-9. doi: 10.5489/cuaj.10023.
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Xp11.2 translocation renal cell carcinoma.Xp11.2 易位性肾细胞癌。
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Rapid development of metastatic Xp11 translocation renal cell carcinoma in a girl treated for neuroblastoma.一名接受神经母细胞瘤治疗的女孩发生转移性Xp11易位肾细胞癌的快速进展。
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Renal cell carcinoma in children and young adults: analysis of clinicopathological, immunohistochemical and molecular characteristics with an emphasis on the spectrum of Xp11.2 translocation-associated and unusual clear cell subtypes.儿童和青年肾细胞癌:临床病理、免疫组化及分子特征分析,重点关注Xp11.2易位相关及不典型透明细胞亚型谱
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Risk assessment of incidentally detected complex renal cysts in children: potential role for a modification of the Bosniak classification.儿童偶然发现的复杂性肾囊肿的风险评估:对博斯尼亚克分类法进行修改的潜在作用
J Urol. 2008 Jul;180(1):317-21. doi: 10.1016/j.juro.2008.03.063. Epub 2008 May 21.
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TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition.TFE3 融合蛋白通过转录上调激活 MET 信号通路,从而将另一类肿瘤定义为 MET 抑制治疗的候选对象。
Cancer Res. 2007 Feb 1;67(3):919-29. doi: 10.1158/0008-5472.CAN-06-2855.
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Population-based study of renal cell carcinoma in children in Germany, 1980-2005: more frequently localized tumors and underlying disorders compared with adult counterparts.1980 - 2005年德国儿童肾细胞癌的基于人群的研究:与成人相比,肿瘤更常为局限性且存在潜在疾病。
Cancer. 2006 Dec 15;107(12):2906-14. doi: 10.1002/cncr.22346.
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