Who let the spikes out?
作者信息
Dulla Chris G, Huguenard John R
机构信息
The authors are at the Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
出版信息
Nat Neurosci. 2009 Aug;12(8):959-60. doi: 10.1038/nn0809-959.
Abstract
摘要
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Is action potential threshold lowest in the axon?动作电位阈值在轴突中是最低的吗？
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Action potential generation requires a high sodium channel density in the axon initial segment.动作电位的产生需要轴突起始段有高钠通道密度。
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Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.在小鼠脊髓感觉神经元中表达的两种轴突钠通道Nav1.2和Nav1.6的电生理特性。
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AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing.锚蛋白G对于电压门控钠通道在轴突起始段的聚集以及正常动作电位发放是必需的。
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