熟能生巧，即使对于呼吸而言也是如此。
Practice makes perfect, even for breathing.
作者信息
Feldman Jack L, Kam Kaiwen, Janczewski Wiktor A
机构信息
The authors are in the Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
出版信息
Nat Neurosci. 2009 Aug;12(8):961-3. doi: 10.1038/nn0809-961.
Abstract
Breathing relies on a respiratory rhythm generator. A study characterizes an early emerging oscillatory group of Phox2b-expressing parafacial cells that entrain and couple with the preBötzinger Complex at the onset of fetal breathing.
摘要
呼吸依赖于呼吸节律发生器。一项研究描述了一组早期出现的表达Phox2b的面神经旁细胞振荡群，它们在胎儿呼吸开始时与前包钦格复合体同步并耦合。
相似文献
1
Practice makes perfect, even for breathing.熟能生巧，即使对于呼吸而言也是如此。
Nat Neurosci. 2009 Aug;12(8):961-3. doi: 10.1038/nn0809-961.
2
Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex.与前包钦格复合体耦合的胚胎旁面神经振荡器的基因鉴定。
Nat Neurosci. 2009 Aug;12(8):1028-35. doi: 10.1038/nn.2354. Epub 2009 Jul 5.
3
Generation of a novel functional neuronal circuit in Hoxa1 mutant mice.Hoxa1突变小鼠中新型功能性神经回路的生成。
J Neurosci. 2001 Aug 1;21(15):5637-42. doi: 10.1523/JNEUROSCI.21-15-05637.2001.
4
Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat.沉默前包钦格复合体中表达生长抑素的神经元会诱发清醒大鼠出现持续性呼吸暂停。
Nat Neurosci. 2008 May;11(5):538-40. doi: 10.1038/nn.2104. Epub 2008 Apr 6.
5
CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat.新生大鼠中，面神经旁呼吸组对二氧化碳敏感的吸气前神经元表达Phox2b。
J Neurosci. 2008 Nov 26;28(48):12845-50. doi: 10.1523/JNEUROSCI.3625-08.2008.
6
MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth.MafB基因缺陷会导致呼吸节律发生异常，并在出生时引发致命的中枢性呼吸暂停。
Nat Neurosci. 2003 Oct;6(10):1091-100. doi: 10.1038/nn1129.
7
Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.在 Phox2b 表达细胞中表达 archaeorhodopsin-3 的转基因大鼠延髓呼吸中枢神经元网络分析。
Brain Res Bull. 2019 Jan;144:39-45. doi: 10.1016/j.brainresbull.2018.11.005. Epub 2018 Nov 15.
8
Distinct roles of Hoxa2 and Krox20 in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening.Hoxa2和Krox20在控制吸气深度、呼吸频率和下颌张开的节律性神经网络发育中的不同作用。
Neural Dev. 2007 Sep 26;2:19. doi: 10.1186/1749-8104-2-19.
9
Background sodium current stabilizes bursting in respiratory pacemaker neurons.背景：钠电流可稳定呼吸起搏器神经元的爆发活动。
J Neurobiol. 2004 Sep 15;60(4):481-9. doi: 10.1002/neu.20050.
10
Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.Zfhx4 的缺失导致小鼠呼吸中枢功能紊乱，进而导致出生后早期死亡。
J Mol Cell Biol. 2021 Jul 6;13(3):210-224. doi: 10.1093/jmcb/mjaa081.
引用本文的文献
1
Role of parafacial nuclei in control of breathing in adult rats.脑桥旁正中核在成年大鼠呼吸控制中的作用。
J Neurosci. 2015 Jan 21;35(3):1052-67. doi: 10.1523/JNEUROSCI.2953-14.2015.
2
Facing the challenge of mammalian neural microcircuits: taking a few breaths may help.面对哺乳动物神经微回路的挑战：做几次深呼吸可能会有所帮助。
J Physiol. 2015 Jan 1;593(1):3-23. doi: 10.1113/jphysiol.2014.277632.
3
Cholinergic neurons in the mouse rostral ventrolateral medulla target sensory afferent areas.小鼠延髓头端腹外侧区的胆碱能神经元投射到感觉传入区域。
Brain Struct Funct. 2013 Mar;218(2):455-75. doi: 10.1007/s00429-012-0408-3. Epub 2012 Mar 30.
4
Active expiration induced by excitation of ventral medulla in adult anesthetized rats.成年麻醉大鼠腹侧髓质兴奋诱导的主动呼气终止。
J Neurosci. 2011 Feb 23;31(8):2895-905. doi: 10.1523/JNEUROSCI.5338-10.2011.
5
Late-expiratory activity: emergence and interactions with the respiratory CpG.呼气末活动：出现及其与呼吸 CpG 的相互作用。
J Neurophysiol. 2010 Nov;104(5):2713-29. doi: 10.1152/jn.00334.2010. Epub 2010 Sep 8.
6
Retrotrapezoid nucleus and parafacial respiratory group.Retrotrapezoid 核和旁面神经呼吸群。
Respir Physiol Neurobiol. 2010 Oct 31;173(3):244-55. doi: 10.1016/j.resp.2010.02.005. Epub 2010 Feb 25.
本文引用的文献
1
Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex.与前包钦格复合体耦合的胚胎旁面神经振荡器的基因鉴定。
Nat Neurosci. 2009 Aug;12(8):1028-35. doi: 10.1038/nn.2354. Epub 2009 Jul 5.
2
Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat.沉默前包钦格复合体中表达生长抑素的神经元会诱发清醒大鼠出现持续性呼吸暂停。
Nat Neurosci. 2008 May;11(5):538-40. doi: 10.1038/nn.2104. Epub 2008 Apr 6.
3
A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.Phox2b基因的人类突变会导致二氧化碳化学感受性缺失、致命性中枢性呼吸暂停以及面神经旁核神经元的特异性缺失。
Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):1067-72. doi: 10.1073/pnas.0709115105. Epub 2008 Jan 15.
4
Congenital central hypoventilation syndrome: PHOX2B genotype determines risk for sudden death.先天性中枢性低通气综合征：PHOX2B基因分型决定猝死风险。
Pediatr Pulmonol. 2008 Jan;43(1):77-86. doi: 10.1002/ppul.20744.
5
Looking for inspiration: new perspectives on respiratory rhythm.寻找灵感：呼吸节律的新视角
Nat Rev Neurosci. 2006 Mar;7(3):232-42. doi: 10.1038/nrn1871.
6
Distinct rhythm generators for inspiration and expiration in the juvenile rat.幼年大鼠中用于吸气和呼气的不同节律发生器。
J Physiol. 2006 Jan 15;570(Pt 2):407-20. doi: 10.1113/jphysiol.2005.098848. Epub 2005 Nov 17.
7
Respiratory control by ventral surface chemoreceptor neurons in rats.大鼠腹侧表面化学感受器神经元对呼吸的控制
Nat Neurosci. 2004 Dec;7(12):1360-9. doi: 10.1038/nn1357. Epub 2004 Nov 21.
8
Developmental gene control of brainstem function: views from the embryo.脑干功能的发育基因调控：来自胚胎的观点。
Prog Biophys Mol Biol. 2004 Feb-Apr;84(2-3):89-106. doi: 10.1016/j.pbiomolbio.2003.11.002.
9
Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation.阿片类药物诱导的量子减慢揭示了呼吸节律产生的双重网络。
Neuron. 2003 Mar 6;37(5):821-6. doi: 10.1016/s0896-6273(03)00092-8.
10
A novel functional neuron group for respiratory rhythm generation in the ventral medulla.延髓腹侧部中一个用于呼吸节律产生的新型功能性神经元群。
J Neurosci. 2003 Feb 15;23(4):1478-86. doi: 10.1523/JNEUROSCI.23-04-01478.2003.
Zotero 插件