Zhao Wen, Liu Yuying, Cahill Catherine M, Yang Wenlu, Rogers Jack T, Huang Xudong
Department of Orthopedics, Beijing Aerospace General Hospital Beijing, China.
Int J Clin Exp Pathol. 2009 May 20;2(6):544-52.
Emerging evidence highlights the importance of the interplay between the bone and immune systems. That evidence bolsters a longstanding recognition that estrogen deficiency, infection, inflammation, and autoimmune disorders are associated with systemic and local bone loss. Yet, only recently has an understanding emerged that T lymphocytes and their products act as key regulators of osteoclast formation, life span, and activity. This review presents this understanding of the process of T lymphocytes and their products mediating osteoporosis and explores some of the most recent findings and hypotheses to explain their action in bone. A more complete appreciation of the interactions between immune and bone cells should lead to targeted therapeutic strategies for diseases that affect either or both systems.
新出现的证据凸显了骨骼与免疫系统之间相互作用的重要性。这一证据支持了长期以来的一种认识，即雌激素缺乏、感染、炎症和自身免疫性疾病与全身性和局部性骨质流失有关。然而，直到最近才认识到T淋巴细胞及其产物是破骨细胞形成、寿命和活性的关键调节因子。本综述阐述了对T淋巴细胞及其产物介导骨质疏松症过程的这一认识，并探讨了一些最新的发现和假说来解释它们在骨骼中的作用。对免疫细胞与骨细胞之间相互作用的更全面理解应该会为影响其中一个或两个系统的疾病带来有针对性的治疗策略。
