Kleyman T R, Cragoe E J
Methods Enzymol. 1990;191:739-55. doi: 10.1016/0076-6879(90)91045-8.
The use of amiloride and its analogs in the study of ion transport requires a knowledge of the pharmacology of inhibition of transport proteins, and of effects on enzymes, receptors, and other cellular processes, such as DNA, RNA, and protein synthesis, and cellular metabolism. We have reviewed the pharmacology of inhibition of these processes by amiloride an its analogs, as well as the use of amiloride analogs as potential probes for the characterization of ion transport systems.
在离子转运研究中使用氨氯吡咪及其类似物，需要了解其对转运蛋白抑制的药理学知识，以及对酶、受体和其他细胞过程（如DNA、RNA和蛋白质合成以及细胞代谢）的影响。我们综述了氨氯吡咪及其类似物对这些过程抑制的药理学，以及氨氯吡咪类似物作为表征离子转运系统潜在探针的应用。
