Passowicz-Muszyńska E, Małolepszy J
Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM, Wrocławiu.
Pneumonol Alergol Pol. 1993;61(7-8):400-4.
Fourteen patients with moderate bronchial asthma were selected for the study. Asthmatics were treated with intravenous salbutamol for one week. Peripheral blood lymphocyte beta-2-adrenergic receptor density and affinity were determined before and after the treatment. To investigate an effect of corticosteroids on beta-2-agonist induced desensitization of beta-2-receptors, beta-2-receptor density and affinity following prednisone administration have been determined in lymphocytes in 7 asthmatics. Patients have been given prednisone in the dose of 20 mg daily for 1 wk after salbutamol discontinuation. Spontaneous recovery of beta-2-adrenergic receptor density in the lymphocytes was estimated in further 7 asthmatics, not given corticosteroids following salbutamol therapy. Our data showed that down-regulation of beta-2-adrenergic receptors improves spontaneously and to significantly higher degree after corticosteroid therapy.
十四名中度支气管哮喘患者被选入该研究。哮喘患者接受静脉注射沙丁胺醇治疗一周。在治疗前后测定外周血淋巴细胞β2肾上腺素能受体密度和亲和力。为了研究皮质类固醇对β2激动剂诱导的β2受体脱敏的影响，已在7名哮喘患者的淋巴细胞中测定了给予泼尼松后β2受体的密度和亲和力。在停用沙丁胺醇后，患者每天服用20mg泼尼松，持续1周。另外7名在沙丁胺醇治疗后未给予皮质类固醇的哮喘患者，评估了淋巴细胞中β2肾上腺素能受体密度的自发恢复情况。我们的数据显示，β2肾上腺素能受体的下调会自发改善，并且在皮质类固醇治疗后改善程度显著更高。
