Ren Xuefeng, Yang Yunhuang, Neville Tracey, Hoyt David, Sparks Daniel, Wang Jianjun
Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Biomol NMR Assign. 2007 Jul;1(1):69-71. doi: 10.1007/s12104-007-9020-5. Epub 2007 Jun 12.
ApoAI is the major protein component of the high-density lipoprotein (HDL) that has been a hot subject of interests because of its anti-atherogenic properties. ApoAI/prebeta-HDL is the most effective acceptors specifically for free cholesterol in human plasma and serves as the precursor of HDL particles. Here we report a complete backbone assignment of human apoAI on a 38 kDa prebetaHDL (Lp1-AI) particle.
载脂蛋白AI是高密度脂蛋白（HDL）的主要蛋白质成分，因其抗动脉粥样硬化特性一直是研究热点。载脂蛋白AI/前β-HDL是人体血浆中游离胆固醇的最有效特异性受体，也是HDL颗粒的前体。在此，我们报道了在38 kDa前β-HDL（Lp1-AI）颗粒上对人载脂蛋白AI进行的完整主链归属。
