蛋白质酪氨酸磷酸酶PTP-BL的28 kDa PDZ2/PDZ3串联结构域的序列特异性氢、碳-13和氮-15主链归属
Sequence-specific (1)H, (13)C, and (15)N backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL.
作者信息
Fetzer Christian P, Sauvageau Janelle, Kock Gerd, Berghaus Carsten, Bangert Jan-Amadé, Dicks Markus, Heumann Rolf, Erdmann Kai S, Stoll Raphael
机构信息
Ruhr-University of Bochum, Germany.
出版信息
Biomol NMR Assign. 2007 Dec;1(2):151-3. doi: 10.1007/s12104-007-9043-y. Epub 2007 Aug 3.
Protein tyrosine phosphatase-basophil like (PTP-BL) represents a large multi domain non-transmembrane scaffolding protein that contains five PDZ domains. Here we report the backbone assignments of the PDZ2/PDZ3 tandem domain of PTP-BL. These assignments now provide a basis for the detailed structural investigation of the interaction between the PDZ domains 2 and 3 of PTP-BL. It will lead to a better understanding of the proposed scaffolding function of this tandem domain in multi-protein complexes assembled by PTB-BL.
蛋白酪氨酸磷酸酶-嗜碱性粒细胞样蛋白（PTP-BL）是一种大型的多结构域非跨膜支架蛋白，包含五个PDZ结构域。在此，我们报道了PTP-BL的PDZ2/PDZ3串联结构域的主链归属。这些归属现在为详细研究PTP-BL的PDZ结构域2和3之间的相互作用提供了基础。这将有助于更好地理解该串联结构域在由PTB-BL组装的多蛋白复合物中所提出的支架功能。
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