人PTPN7 34 kDa催化结构域的序列特异性1H、13C和15N主链共振归属
Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7.
作者信息
Jeeves Mark, McClelland Darren M, Barr Alastair J, Overduin Michael
机构信息
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
出版信息
Biomol NMR Assign. 2008 Dec;2(2):101-3. doi: 10.1007/s12104-008-9095-7. Epub 2008 May 30.
PMID:19636879
Abstract
PTPN7 is a protein tyrosine phosphatase responsible for inactivation of MAPK in leukocytes. Here we report the backbone resonance assignments of the 34 kDa phosphatase domain of human PTPN7, which is amplified in myeloid malignancies and deleted in lymphoproliferative disorders.
摘要
PTPN7是一种蛋白质酪氨酸磷酸酶，负责白细胞中MAPK的失活。在此，我们报告了人类PTPN7 34 kDa磷酸酶结构域的主链共振归属，该结构域在髓系恶性肿瘤中扩增，在淋巴增殖性疾病中缺失。
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