Bottomley Matthew James, Muraglia Ester, Bazzo Renzo
Istituto di Ricerche di Biologia Molecolare, Pomezia, Roma, Italy.
Biomol NMR Assign. 2007 Dec;1(2):237-9. doi: 10.1007/s12104-007-9066-4. Epub 2007 Nov 30.
LasR regulates toxin production in Pseudomonas aeruginosa and its inhibition can attenuate the virulence of this opportunistic human pathogen. To aid studies of interactions with inhibitors, we report the NMR backbone assignments for the dimeric LasR ligand-binding domain.
LasR调节铜绿假单胞菌中的毒素产生,对其抑制可减弱这种机会性人类病原体的毒力。为了有助于研究与抑制剂的相互作用,我们报告了二聚体LasR配体结合结构域的核磁共振主链归属。