1H and 15N resonance assignment of the second fibronectin type III module of the neural cell adhesion molecule.
作者信息
Kiselyov Vladislav V, Berezin Vladimir, Bock Elisabeth, Poulsen Flemming M
机构信息
Protein Laboratory, Institute of Molecular Pathology, Blegdamsvej 3, Copenhagen, Denmark.
出版信息
Biomol NMR Assign. 2008 Dec;2(2):171-3. doi: 10.1007/s12104-008-9113-9. Epub 2008 Sep 28.
We report here the NMR assignment of the second fibronectin type III module of the neural cell adhesion molecule (NCAM). This module has previously been shown to interact with the fibroblast growth factor receptor (FGFR), and the FGFR-binding site was mapped by NMR to the FG-loop region of the module. The FG-loop region also contains a putative nucleotide-binding motif, which was shown by NMR to interact with ATP. Furthermore, ATP was demonstrated to inhibit binding of the second F3 module of NCAM to FGFR.
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