CPAP蛋白微管蛋白相互作用亚结构域PN2-3的核磁共振波谱归属
NMR assignment of PN2-3, a tubulin interaction subdomain of the CPAP protein.
作者信息
Clément Marie-Jeanne, Savarin Philippe, Coutant Jérôme, Toma Flavio, Curmi Patrick
机构信息
Laboratoire Structure-Activité des Biomolécules Normales et Pathologiques, INSERM/UEVE U829-Université Evry-Val d'Essonne, Bâtiment Maupertuis, 91025, Evry, France.
出版信息
Biomol NMR Assign. 2008 Dec;2(2):115-7. doi: 10.1007/s12104-008-9099-3. Epub 2008 Jun 24.
PMID:19636883
Abstract
We report the NMR assignment of the PN2-3 subdomain of the CPAP protein. It has been previously shown that this motif interacts with tubulin, inhibits microtubule nucleation from the centrosome and depolymerizes taxol-stabilized microtubules.
摘要
我们报道了CPAP蛋白PN2-3亚结构域的核磁共振（NMR）归属。先前已经表明，该基序与微管蛋白相互作用，抑制来自中心体的微管成核，并使紫杉醇稳定的微管解聚。
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