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嗜热栖热菌中咪唑甘油磷酸（IGP）合酶蛋白HisF的1H、15N和13C共振归属

1H, 15N and 13C resonance assignment of imidazole glycerol phosphate (IGP) synthase protein HisF from Thermotoga maritima.

作者信息

Lipchock James M, Loria J Patrick

机构信息

Department of Chemistry, Yale University, Sterling Chemistry Laboratory, New Haven, CT, 06511, USA.

出版信息

Biomol NMR Assign. 2008 Dec;2(2):219-21. doi: 10.1007/s12104-008-9125-5. Epub 2008 Oct 7.

DOI:10.1007/s12104-008-9125-5
PMID:19636909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2907236/
Abstract

HisF comprises one half of the heterodimeric protein complex imidazole glycerol phosphate (IGP) synthase responsible for the fifth step of histidine biosynthesis. Here we report backbone and side chain assignments necessary for characterization of protein dynamics involved in the allosteric mechanism of IGP synthase.

摘要

HisF是负责组氨酸生物合成第五步的异二聚体蛋白复合物咪唑甘油磷酸（IGP）合酶的一半。在此，我们报告了表征IGP合酶变构机制中涉及的蛋白质动力学所需的主链和侧链归属。

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1H, 15N and 13C resonance assignment of imidazole glycerol phosphate (IGP) synthase protein HisF from Thermotoga maritima.嗜热栖热菌中咪唑甘油磷酸（IGP）合酶蛋白HisF的1H、15N和13C共振归属
Biomol NMR Assign. 2008 Dec;2(2):219-21. doi: 10.1007/s12104-008-9125-5. Epub 2008 Oct 7.
2
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Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex.来自嗜热栖热菌的咪唑甘油磷酸合酶。双酶复合物的四级结构、稳态动力学及反应机制。
J Biol Chem. 2001 Jun 8;276(23):20387-96. doi: 10.1074/jbc.M102012200. Epub 2001 Mar 22.
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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.通过偶极-偶极耦合和化学位移各向异性的相互抵消而导致的T2弛豫减弱，为溶液中非常大的生物大分子的核磁共振结构提供了一条途径。
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NMRPipe: a multidimensional spectral processing system based on UNIX pipes.NMRPipe：一个基于UNIX管道的多维光谱处理系统。
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The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data.13C化学位移指数：一种利用13C化学位移数据鉴定蛋白质二级结构的简单方法。
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