Zaninotto Ana L C, Bueno Orlando F A, Pradella-Hallinan Márcia, Tufik Sérgio, Rusted Jenny, Stough Con, Pompéia Sabine
Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil.
Hum Psychopharmacol. 2009 Aug;24(6):453-64. doi: 10.1002/hup.1044.
The acute nootropic potential of donepezil in young healthy volunteers has not been adequately investigated mainly because in previous studies: (1) effects were assessed before peak-plasma concentration (Tmax) was reached; (2) only a few cognitive processes were assessed. Here we investigated a myriad of cognitive effects of augmentation of acetylcholine using an acute dose of donepezil in healthy adults at theoretical Tmax.
This was a double-blind, placebo controlled, parallel group design study of cognitive effects of acute oral donepezil (5 mg). Subjects were tested twice after donepezil ingestion: 90 min (time that coincides with previous testing in the literature) and 210 min. (theoretical Tmax). The test battery included tasks that tap cognitive domains that are sensitive to acetylcholine manipulations.
At both testing times donepezil improved long-term recall of prose, objects recall, recall of spatial locations, and integration of objects with their locations, some effects having been related to self-reported mood enhancement. However, improvement of performance in the central executive measure (backward digit span) occurred only at Tmax.
Positive cognitive effects of acute donepezil can be observed in various cognitive domains including mood, but its full nootropic potential is more clearly found close to theoretical peak-plasma concentration.
多奈哌齐对年轻健康志愿者的急性促智潜力尚未得到充分研究，主要原因是在以往研究中：（1）在达到血浆峰浓度（Tmax）之前评估效果；（2）仅评估了少数认知过程。在此，我们在理论Tmax时使用急性剂量的多奈哌齐，研究了健康成年人中增强乙酰胆碱对多种认知的影响。
这是一项关于急性口服多奈哌齐（5毫克）认知效果的双盲、安慰剂对照、平行组设计研究。在摄入多奈哌齐后，对受试者进行了两次测试：90分钟（与文献中先前测试时间一致）和210分钟（理论Tmax）。测试组包括对乙酰胆碱操作敏感的认知领域的任务。
在两个测试时间点，多奈哌齐均改善了散文的长期记忆、物体记忆、空间位置记忆以及物体与其位置的整合，一些效果与自我报告的情绪改善有关。然而，仅在Tmax时，中央执行功能测量（倒背数字广度）的表现有所改善。
急性多奈哌齐在包括情绪在内的各种认知领域均可观察到积极的认知效果，但其完整的促智潜力在接近理论血浆峰浓度时更为明显。
