Tian Jun, Liao Gui-Qing, Liu Hai-Chao, Li Chuan-Zhen, Li Qing, Wang Jing-Xu, Du Ri-Chang, Zhang Tong-Han
Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital, Sun Yat-Sen University, Guangzhou 510055, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2009 Jun;27(3):326-9.
To establish transplanted models of VX2 tongue carcinoma in rabbits by three methods and compare these models.
After establishment of VX2 tumor-bearing rabbits, 72 New-Zealand white rabbits were randomly divided into 3 groups. Intact tumour tissue, modified tumour cell suspension, tumour cell suspension were respectively injected into the middle-third lateral border of the tongues of rabbits in 3 groups to induce transplanted VX2 tongue carcinoma. The histological features, the tumour-take rates and the metastasis rates of the 3 models were observed.
The tumour-take rate of 3 models were 83.3%, 91.7% and 33.3% respectively; the lymph node metastasis rates were 71.4%, 100.0% and 37.5% respectively; the lung metastasis rates were 35.7%, 81.3% and 0 respectively. The histological features of the transplanted VX2 tongue carcinoma of 3 models were all consistent with those of moderately differentiated carcinoma.
The biological properties of the transplanted VX2 tongue carcinoma of 3 models is much alike to tongue carcinoma in humans. The model established with modified tumor cell suspension is considered to be more suitable for tongue cancer study.
采用三种方法建立兔VX2舌癌移植模型并进行比较。
建立VX2荷瘤兔后，将72只新西兰白兔随机分为3组。分别将完整肿瘤组织、改良肿瘤细胞悬液、肿瘤细胞悬液注入3组兔舌中1/3外侧缘诱导移植VX2舌癌。观察3种模型的组织学特征、成瘤率及转移率。
3种模型的成瘤率分别为83.3%、91.7%和33.3%；淋巴结转移率分别为71.4%、100.0%和37.5%；肺转移率分别为35.7%、81.3%和0。3种模型移植VX2舌癌的组织学特征均与中分化癌相符。
3种模型移植VX2舌癌的生物学特性与人类舌癌相似。改良肿瘤细胞悬液建立的模型更适合舌癌研究。
