Ogawa Seiji, Urabe Daisuke, Yokokura Yoshiyuki, Arai Hiroyuki, Arita Makoto, Inoue Masayuki
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Lett. 2009 Aug 20;11(16):3602-5. doi: 10.1021/ol901350g.
Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil infiltration and reducing proinflammatory cytokines in the acute peritonitis model.
消退素E2是一种强效抗炎化合物，由二十碳五烯酸衍生而来。本文报道了利用其固有的假对映体亚结构高效全合成消退素E2的方法。合成的消退素E2在急性腹膜炎模型中显示出具有阻止中性粒细胞浸润和减少促炎细胞因子的生物活性。
