Kadota S, Takamori Y, Nyein K N, Kikuchi T, Tanaka K, Ekimoto H
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1990 Oct;38(10):2687-97. doi: 10.1248/cpb.38.2687.
Woodfruticosin (woodfordin C), a new cyclic dimeric hydrolyzable tannin having an inhibitory activity toward deoxyribonucleic acid (DNA) topoisomerase II, has been isolated from the leaves of Woodfordia fruticosa Kurz (Lythraceae) along with three known flavonol glycosides and three known flavonol glycoside gallates. The structure of wood fruticosin (woodfordin C) was determined by the use of two-dimensional nuclear magnetic resonance (2-D NMR) spectroscopy including heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC) techniques. Detailed analyses of the proton and carbon-13 NMR (1H- and 13C-NMR) spectra of six known flavonoids were performed.
从假繁缕（千屈菜科）的叶子中分离出了一种新的具有对脱氧核糖核酸（DNA）拓扑异构酶II抑制活性的环状二聚体可水解单宁——木弗鲁蒂辛（木弗鲁汀C），同时还分离出了三种已知的黄酮醇糖苷和三种已知的黄酮醇糖苷没食子酸酯。通过使用包括异核多量子相干（HMQC）和异核多键连接（HMBC）技术在内的二维核磁共振（2-D NMR）光谱法确定了木弗鲁蒂辛（木弗鲁汀C）的结构。对六种已知黄酮类化合物的质子和碳-13核磁共振（1H-和13C-NMR）光谱进行了详细分析。
