Hayashi Y, Fukushima S, Kishimoto S, Nakano M
Department of Pharmacy, Kumamoto University Hospital, Japan.
Chem Pharm Bull (Tokyo). 1990 Oct;38(10):2874-6. doi: 10.1248/cpb.38.2874.
The release profiles of a free polyunsaturated fatty acid, alpha-linolenic acid, from solutions in an oily lymphographic agent Lipiodol-Ultra-Fluid (Lipiodol), to rabbit and human plasma, phosphate buffer solution (PBS), and PBS containing bovine serum albumin (BSA) were examined in vitro. The times required for 50% release of alpha-linolenic acid from Lipiodol were about 1 and 1.5 h in the rabbit and human plasma, respectively. Although only a slight amount of alpha-linolenic acid was released from Lipiodol to PBS after 24 h incubation at 37 degrees C, release was markedly enhanced by the addition of BSA to PBS. The amount of alpha-linolenic acid released from Lipiodol into PBS containing 5% BSA increased as the alpha-linolenic acid content in Lipiodol was increased. In all experiments, the release had stopped before all alpha-linolenic acid had been released. The prolongation of alpha-linolenic acid release from Lipiodol is considered a requisite for a selective anticancer effect of Lipiodol containing a free fatty acid on liver cancer.
在体外研究了游离多不饱和脂肪酸α-亚麻酸从油性淋巴造影剂超液态碘化油（Lipiodol）溶液中向兔和人血浆、磷酸盐缓冲溶液（PBS）以及含牛血清白蛋白（BSA）的PBS中的释放情况。α-亚麻酸从碘化油中释放50%所需时间在兔血浆和人血浆中分别约为1小时和1.5小时。在37℃孵育24小时后，尽管只有少量α-亚麻酸从碘化油释放到PBS中，但向PBS中添加BSA后释放明显增强。从碘化油释放到含5% BSA的PBS中的α-亚麻酸量随着碘化油中α-亚麻酸含量的增加而增加。在所有实验中，在所有α-亚麻酸释放之前释放就已停止。α-亚麻酸从碘化油中的释放延长被认为是含游离脂肪酸的碘化油对肝癌具有选择性抗癌作用的必要条件。
