Ganda Clarissa, Schwab Sibylle G, Amir Nurmiati, Heriani Heriani, Irmansyah Irman, Kusumawardhani Agung, Nasrun Martina, Widyawati Ika, Maier Wolfgang, Wildenauer Dieter B
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, WA, Australia.
Int J Neuropsychopharmacol. 2009 Oct;12(9):1283-9. doi: 10.1017/S1461145709990356. Epub 2009 Jul 29.
We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.
我们之前报道过，在一个来自印度尼西亚的同胞对家系样本中，全基因组与3号染色体短臂存在显著连锁。连锁区域内一个有潜力的候选基因是代谢型谷氨酸受体7亚型（GRM7），它参与谷氨酸能神经传递。我们对124个印度尼西亚同胞对家系样本中的GRM7基因的18个单核苷酸多态性进行了基因分型，这些家系样本曾提供过显著的连锁发现。传递不平衡分析显示，GRM7基因内含子1中的rs17031835存在名义上显著的传递畸变（p=0.004，多重检验校正前），以及包含rs17031835的单倍型。在我们的样本中，未发现其他单个标记与精神分裂症有显著关联。我们的研究结果支持了谷氨酸能神经传递，特别是GRM7基因可能与精神分裂症的发生有关这一观点。有必要进行进一步的研究来支持这一发现。
