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Profiling the Impact of mGlu/Elfn1 Protein Interactions on the Pharmacology of mGlu Allosteric Modulators.
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Potentiation of group III metabotropic glutamate receptors positively affects neurophysiological features in a mouse model of Rett syndrome.
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mGlu4R, mGlu7R, and mGlu8R allosteric modulation for treating acute and chronic neurodegenerative disorders.
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Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders.
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Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7.
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GRM7 gene mutations and consequences for neurodevelopment.
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Persistent challenges in the development of an mGlu PAM in vivo tool compound: The discovery of VU6046980.
Bioorg Med Chem Lett. 2023 Jan 15;80:129106. doi: 10.1016/j.bmcl.2022.129106. Epub 2022 Dec 15.

本文引用的文献

1
Synthesis and SAR of a series of mGlu NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core.
Bioorg Med Chem Lett. 2020 Nov 15;30(22):127529. doi: 10.1016/j.bmcl.2020.127529. Epub 2020 Sep 2.
2
Surveying heterocycles as amide bioisosteres within a series of mGlu NAMs: Discovery of VU6019278.
Bioorg Med Chem Lett. 2019 May 15;29(10):1211-1214. doi: 10.1016/j.bmcl.2019.03.016. Epub 2019 Mar 15.
4
Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.
Front Mol Neurosci. 2018 Oct 23;11:387. doi: 10.3389/fnmol.2018.00387. eCollection 2018.
5
VU6010608, a Novel mGlu NAM from a Series of -(2-(1-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides.
ACS Med Chem Lett. 2017 Nov 8;8(12):1326-1330. doi: 10.1021/acsmedchemlett.7b00429. eCollection 2017 Dec 14.
6
Discovery of VU6005649, a CNS Penetrant mGlu Receptor PAM Derived from a Series of Pyrazolo[1,5-]pyrimidines.
ACS Med Chem Lett. 2017 Sep 1;8(10):1110-1115. doi: 10.1021/acsmedchemlett.7b00317. eCollection 2017 Oct 12.
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10
Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network.
Front Neural Circuits. 2016 Apr 25;10:31. doi: 10.3389/fncir.2016.00031. eCollection 2016.

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