内皮型一氧化氮合酶 G894T 多态性与腹主动脉瘤。
eNOS G894T polymorphism and abdominal aortic aneurysms.
机构信息
Department of Cardiovascular Surgery, Urfa State Hospital, Urfa, Turkey.
出版信息
Angiology. 2010 Feb;61(2):125-30. doi: 10.1177/0003319709339589. Epub 2009 Jul 27.
BACKGROUND
The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm (AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase (eNOS) gene polymorphism with AAA.
METHODS
eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique.
RESULTS
eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P = .01, P = .03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs.
CONCLUSION
The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.
背景
导致腹主动脉瘤（AAA）风险的遗传风险因素尚未完全清楚。我们评估了内皮型一氧化氮合酶（eNOS）基因多态性与 AAA 的关系。
方法
通过聚合酶链反应（PCR）-限制技术分析 61 例 AAA 患者和 62 例对照参与者的 eNOS 基因多态性。
结果
AAA 患者的 eNOS G894 纯合子 T/T 基因型多态性和 894T 等位基因频率明显高于对照组（P=.01，P=.03）。在 AAA 患者中，eNOS G894 T/T 多态性和 894T 等位基因频率与更大的 AAA 相关。
结论
本研究在一小部分参与者中显示，eNOS G894T 多态性与 AAA 之间存在关系。
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