环氧化酶-2过表达是早期高分化肝细胞癌的一个特征，预后良好。
Cyclo-oxygenase-2 overexpression is a feature of early and well-differentiated hepatocellular carcinoma with a favourable prognosis.
作者信息
Schmitz K J, Wohlschlaeger J, Lang H, Sotiropoulos G C, Kaiser G M, Schmid K W, Baba H A
机构信息
Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45122, Germany.
出版信息
J Clin Pathol. 2009 Aug;62(8):690-3. doi: 10.1136/jcp.2009.065888.
AIMS
To determine the prognostic relevance of cyclo-oxygenase-2 (COX-2) expression in hepatocellular carcinoma (HCC) and its relationship to important clinicopathological parameters.
METHODS
A series of 196 patients with HCCs treated either by surgical resection (n = 106) or liver transplantation (n = 90) was investigated. Immunohistochemically confirmed COX-2 expression was correlated with a series of clinicopathologically relevant parameters as well as proliferative activity and apoptosis.
RESULTS
Overexpression of COX-2 correlated statistically with high histological tumour differentiation (p<0.001) and early TNM stage (p = 0.003). COX-2 overexpression was associated with lower apoptotic rates (p = 0.001), whereas proliferation activity did not differ significantly. In addition, COX-2 overexpression showed a significant correlation with favourable overall survival (p<0.001). In multivariate survival analysis, COX-2 expression qualified as an independent prognostic parameter (p = 0.030).
CONCLUSIONS
Overexpression of COX-2 in HCC indicates early-stage cancer with less aggressive tumour behaviour and constitutes an independent prognostic factor.
目的
确定环氧化酶-2（COX-2）在肝细胞癌（HCC）中的表达与预后的相关性及其与重要临床病理参数的关系。
方法
对196例接受手术切除（n = 106）或肝移植（n = 90）治疗的HCC患者进行了研究。免疫组织化学证实的COX-2表达与一系列临床病理相关参数以及增殖活性和细胞凋亡相关。
结果
COX-2的过表达与高组织学肿瘤分化（p<0.001）和早期TNM分期（p = 0.003）在统计学上相关。COX-2过表达与较低的凋亡率相关（p = 0.001），而增殖活性无显著差异。此外，COX-2过表达与良好的总生存期显著相关（p<0.001）。在多因素生存分析中，COX-2表达是一个独立的预后参数（p = 0.030）。
结论
HCC中COX-2的过表达表明癌症处于早期，肿瘤行为侵袭性较小，并且是一个独立的预后因素。
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