Department of Medical Oncology, Cancer Center of West China Hospital, Sichuan University, Chengdu, China.
Med Oncol. 2011 Sep;28(3):796-803. doi: 10.1007/s12032-010-9519-y. Epub 2010 Apr 17.
Cox-2, Survivin and Bcl-2 are frequently overexpressed in numerous types of cancers. They are known to be the important regulators of apoptosis. This study was designed to investigate the correlation between the clinical characteristics and the expression of Cox-2, Survivin and Bcl-2 in hepatocellular carcinoma. A total of 63 postoperative hepatocellular carcinoma (HCC) samples, 10 adjacent non-tumor samples and 10 normal liver samples were immunochemically detected for the expression of Cox-2, Survivin and Bcl-2. A median follow-up of 4 years for the 63 HCC patients was conducted. Univariate tests and multivariate Cox regression were performed for statistical analysis. The Kaplan-Meier method was used to analyze the survival. Positive expression of Cox-2 (84.3%) and Survivin (77.8%) was detected significantly more frequently in the HCC samples than in the normal liver tissues (30% and 0, respectively). Bcl-2 was highly expressed in the adjacent non-tumor tissue. Cox-2 was positively correlative to Survivin. Survivin and Bcl-2 were significantly associated with the pathological grade of HCC (P<0.05). Expression of both Cox-2 and Survivin was significantly associated with the poor overall survival (OS) (P=0.0141, P=0.0039). Furthermore, multivariate analysis confirmed the independent prognostic value of Survivin expression, along with tumor size and hepatic function. Cox-2 and Survivin were highly expressed in the HCC tissue. Survivin and Bcl-2 were significantly associated with the pathological grade of HCC. The expression of Survivin was an independent prognostic factor for HCC after a hepatectomy. Treatment that inhibits Survivin may be a promising targeted approach in HCC.
Cox-2、Survivin 和 Bcl-2 在多种癌症中常过度表达，它们被认为是细胞凋亡的重要调节因子。本研究旨在探讨 Cox-2、Survivin 和 Bcl-2 在肝癌中的表达与临床特征的相关性。采用免疫组化法检测 63 例肝癌术后组织、10 例癌旁非肿瘤组织和 10 例正常肝组织中 Cox-2、Survivin 和 Bcl-2 的表达情况，对 63 例肝癌患者进行了 4 年的中位随访。对所有数据进行单因素和多因素 Cox 回归分析。Kaplan-Meier 法用于分析生存情况。结果显示，肝癌组织中 Cox-2（84.3%）和 Survivin（77.8%）的阳性表达率明显高于正常肝组织（分别为 30%和 0），Bcl-2 在癌旁非肿瘤组织中高表达。Cox-2 与 Survivin 呈正相关。Survivin 和 Bcl-2 与肝癌的病理分级显著相关（P<0.05）。Cox-2 和 Survivin 的表达与患者的总生存（OS）显著相关（P=0.0141，P=0.0039）。多因素分析证实，Survivin 的表达与肿瘤大小和肝功能一起是独立的预后因素。Cox-2 和 Survivin 在肝癌组织中高表达，Survivin 和 Bcl-2 与肝癌的病理分级显著相关。Survivin 的表达是肝癌患者肝切除术后的独立预后因素。抑制 Survivin 的治疗可能是肝癌有前途的靶向治疗方法。
