Nesterova L A, Shaĭymov B K, Manukhin B N
Fiziol Zh SSSR Im I M Sechenova. 1990 Sep;76(9):1159-64.
Adrenergic response to noradrenaline and specific agonists of alpha- and beta-adrenoceptors phenylephrine and isopropylnoradrenaline, as well as the effect of the alpha-adrenoceptors blockers on the functional state of beta-adrenoceptors and vice versa, were studied in the rat isolated portal vein. Functional interaction between alpha- and beta-adrenoceptors was manifested in a change of alpha-receptors when beta-receptors were blocked, and a change of reaction of beta-receptors when the alpha ones were blocked. The blockade of specific receptors seems to evoke conformational changes of cell membrane, thus modulating the affinity to the agonist of the receptors of the other type.
在大鼠离体门静脉中研究了对去甲肾上腺素以及α和β肾上腺素能受体的特异性激动剂去氧肾上腺素和异丙肾上腺素的肾上腺素能反应，以及α肾上腺素能受体阻滞剂对β肾上腺素能受体功能状态的影响，反之亦然。α和β肾上腺素能受体之间的功能相互作用表现为，当β受体被阻断时α受体发生变化，而当α受体被阻断时β受体的反应发生变化。特异性受体的阻断似乎引起细胞膜的构象变化，从而调节对另一种类型受体激动剂的亲和力。
