Nesterova L A, Manukhin B N
Fiziol Zh SSSR Im I M Sechenova. 1985 Jul;71(7):904-9.
Effect of desensitization of alpha-adrenoreceptors on the functional state of beta-receptors and vice versa was studied in isolated sections of the rat small intestine. Neither blockade, nor desensitization of alpha-receptors produced any effect on the sensitivity of beta-receptors to isopropyl-noradrenaline (IPN) whereas desensitization of beta-receptors to IPN resulted in the increase of alpha-receptors sensitivity to phenylephrine with a decreased maximal reaction. In the presence of GTP (0.02 mM) and propranolol (2.00 x 10(-7) M) IPN acts as a competitive reversible auto-inhibitor, GTP fully removing the inhibitory effect of IPN on both alpha- and beta-adrenoreceptors. Existence of functional interrelationship between alpha- and beta-adrenoreceptors is suggested.
在大鼠小肠的离体切片中研究了α-肾上腺素能受体脱敏对β-受体功能状态的影响，反之亦然。α-受体的阻断或脱敏对β-受体对异丙基去甲肾上腺素（IPN）的敏感性均无任何影响，而β-受体对IPN的脱敏导致α-受体对去氧肾上腺素的敏感性增加，最大反应降低。在存在GTP（0.02 mM）和普萘洛尔（2.00×10⁻⁷ M）的情况下，IPN作为竞争性可逆性自身抑制剂，GTP完全消除了IPN对α-和β-肾上腺素能受体的抑制作用。提示α-和β-肾上腺素能受体之间存在功能相互关系。
