Ledneva I P, Manukhin B N
Fiziol Zh SSSR Im I M Sechenova. 1985 Oct;71(10):1276-81.
In isolated sections of the rat small intestine, adrenergic responses to phenylephrine (P), noradrenaline (NA) and isopropylnoradrenaline (IN) were studied at various temperatures of the incubation medium. Raise of the temperature from 33 to 37 degrees C increased the sensitivity of adrenoreceptors to P and NA 3.2-and 2.1-fold but did not change the sensitivity to IN. This change of adrenoreactivity was eliminated by phentolamine blockade of alpha-adrenoreceptors, and the raise of temperature always produced a decrease in maximal reaction of the small intestine. The change of adrenoreceptors of the small intestine smooth muscles seems to be related primarily to the rearrangement of alpha-adrenoreceptors.
在大鼠小肠的离体节段中，研究了在孵育介质的不同温度下，去氧肾上腺素（P）、去甲肾上腺素（NA）和异丙肾上腺素（IN）的肾上腺素能反应。孵育介质温度从33℃升高到37℃时，肾上腺素受体对P和NA的敏感性分别增加了3.2倍和2.1倍，但对IN的敏感性未改变。酚妥拉明对α-肾上腺素受体的阻断消除了这种肾上腺素反应性的变化，且温度升高总是导致小肠最大反应降低。小肠平滑肌肾上腺素受体的变化似乎主要与α-肾上腺素受体的重排有关。
