脊椎动物视网膜中的磷酯酰肌醇 3-激酶信号转导。
Phosphoinositide 3-kinase signaling in the vertebrate retina.
机构信息
Departments of Ophthalmology and Cell Biology, and Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. r
出版信息
J Lipid Res. 2010 Jan;51(1):4-22. doi: 10.1194/jlr.R000232.
Abstract
The phosphoinositide (PI) cycle, discovered over 50 years ago by Mabel and Lowell Hokin, describes a series of biochemical reactions that occur on the inner leaflet of the plasma membrane of cells in response to receptor activation by extracellular stimuli. Studies from our laboratory have shown that the retina and rod outer segments (ROSs) have active PI metabolism. Biochemical studies revealed that the ROSs contain the enzymes necessary for phosphorylation of phosphoinositides. We showed that light stimulates various components of the PI cycle in the vertebrate ROS, including diacylglycerol kinase, PI synthetase, phosphatidylinositol phosphate kinase, phospholipase C, and phosphoinositide 3-kinase (PI3K). This article describes recent studies on the PI3K-generated PI lipid second messengers in the control and regulation of PI-binding proteins in the vertebrate retina.
摘要
磷酸肌醇（PI）循环是由 Mabel 和 Lowell Hokin 于 50 多年前发现的，它描述了一系列生化反应，这些反应发生在细胞的质膜内层，以响应细胞外刺激对受体的激活。我们实验室的研究表明，视网膜和视杆外节（ROS）具有活跃的 PI 代谢。生化研究表明，ROS 含有磷酸肌醇磷酸化所需的酶。我们表明，光刺激脊椎动物 ROS 中 PI 循环的各种成分，包括二酰基甘油激酶、PI 合成酶、磷酸肌醇磷酸激酶、磷脂酶 C 和磷酸肌醇 3-激酶（PI3K）。本文描述了最近关于 PI3K 在脊椎动物视网膜中控制和调节与 PI 结合蛋白的 PI 脂第二信使的研究。
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