高渗应激下的视网膜胰岛素受体信号传导
Retinal insulin receptor signaling in hyperosmotic stress.
作者信息
Rajala Raju V S, Ivanovic Ivana, Dilly Ashok Kumar
机构信息
Department of Opthamology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
出版信息
Vitam Horm. 2009;80:583-612. doi: 10.1016/S0083-6729(08)00620-1.
Abstract
In the diabetic eye, the increased accumulation of sorbitol in the retina has been implicated in the pathogenesis of diabetic retinopathy (DR). Neurodegeneration is an important component of DR as demonstrated by increased neural apoptosis in the retina during experimental and human diabetes. Insulin receptor (IR) activation has been shown to rescue retinal neurons from apoptosis through a phosphoinositide 3-kinase and protein kinase B (Akt) survival cascade. In this study, we examined the IR signaling in sorbitol-induced hyperosmotic stressed retinas.
摘要
在糖尿病性眼病中，视网膜中山梨醇积累的增加与糖尿病视网膜病变（DR）的发病机制有关。神经退行性变是DR的一个重要组成部分，实验性糖尿病和人类糖尿病期间视网膜中神经细胞凋亡增加就证明了这一点。胰岛素受体（IR）激活已被证明可通过磷脂酰肌醇3激酶和蛋白激酶B（Akt）存活级联反应使视网膜神经元免于凋亡。在本研究中，我们检测了山梨醇诱导的高渗应激视网膜中的IR信号传导。
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