Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
J Lipid Res. 2010 Mar;51(3):468-71. doi: 10.1194/jlr.R000034. Epub 2009 Jul 28.
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.
已在真核生物物种中鉴定出 PAT 家族蛋白，这些物种包括脊椎动物、昆虫和变形虫。这些蛋白质具有高度保守的序列组织，对细胞内中性脂质储存滴的表面具有亲和力。目前，各种成员的命名法缺乏一致性和精确性，更多地来自历史背景，而不是对进化关系和共享功能的认识。在与小鼠基因组命名委员会、人类基因组组织基因组命名委员会以及 2007 年 FASEB 关于脂质滴的会议的与会者协商后，我们为基因和蛋白家族成员建立了一个统一的命名法。每个基因成员都将包含 PAT 家族的创始基因 PERILIPIN（PLIN），并用不同的基因/蛋白质按顺序编号。
