Saito Mitsuru
Department of Orthopaedic Surgery, Jikei University School of Medicine.
Clin Calcium. 2009 Aug;19(8):1192-9.
Vitamin C and a vitamin B are essential nutrients to maintain bone density and bone quality. Recent literature clearly shows that vitamin C and B affect bone quality determinant "collagen cross-link formation" . Mildly elevated plasma homocysteine levels induced by vitamin B insufficiency and methylenetetrahydrofolate reductase (MTHFR) deteriorate normal collagen cross-link formation (Saito M, Osteoporos Int 2009 May 30. [Epub ahead of print] , Shiraki M and Saito M, J Bone Miner Metab [6] 2008) . In this review, we describe the effects of vitamin C and vitamin B insufficiency and hyperhomocysteinemia on bone quality in terms of collagen cross-link formation in bone that have been reported in the literature.
维生素C和维生素B是维持骨密度和骨质的必需营养素。最近的文献清楚地表明，维生素C和B会影响骨质决定因素“胶原蛋白交联形成”。维生素B缺乏和亚甲基四氢叶酸还原酶（MTHFR）诱导的血浆同型半胱氨酸水平轻度升高会使正常的胶原蛋白交联形成恶化（斋藤M，《骨质疏松症国际》2009年5月30日。[电子版优先发表]，白木M和斋藤M，《骨矿物质代谢杂志》[6]2008年）。在本综述中，我们根据文献报道的骨中胶原蛋白交联形成情况，描述了维生素C和维生素B缺乏以及高同型半胱氨酸血症对骨质的影响。
