Barnett Joshua M, Yanni Susan E, Penn John S
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Doc Ophthalmol. 2010 Feb;120(1):3-12. doi: 10.1007/s10633-009-9180-y. Epub 2009 Jul 29.
Retinopathy of prematurity (ROP) is a potentially blinding disease affecting premature infants. ROP is characterized by pathological ocular angiogenesis or retinal neovascularization (NV). Models of ROP have yielded much of what is currently known about physiological and pathological blood vessel growth in the retina. The rat provides a particularly attractive and cost effective model of ROP. The rat model of ROP consistently produces a robust pattern of NV, similar to that seen in humans. This model has been used to study gross aspects of angiogenesis. More recently, it has been used to identify and therapeutically target specific genes and molecular mechanisms involved in the angiogenic cascade. As angiogenesis occurs as a complication of many diseases, knowledge gained from these studies has the potential to impact nonocular angiogenic conditions. This article provides historical perspective on the development and use of the rat model of ROP. Key findings generated through the use of this model are also summarized.
早产儿视网膜病变（ROP）是一种可能导致失明的疾病，影响早产儿。ROP的特征是病理性眼部血管生成或视网膜新生血管形成（NV）。ROP模型为目前已知的视网膜生理和病理血管生长提供了很多信息。大鼠提供了一个特别有吸引力且具有成本效益的ROP模型。ROP大鼠模型始终会产生强大的NV模式，类似于人类所见。该模型已用于研究血管生成的总体方面。最近，它已被用于识别和治疗靶向血管生成级联反应中涉及的特定基因和分子机制。由于血管生成是许多疾病的并发症，从这些研究中获得的知识有可能影响非眼部血管生成疾病。本文提供了关于ROP大鼠模型的开发和使用的历史视角。还总结了通过使用该模型产生的关键发现。
