Amir Lisa R, Everts Vincent, Bronckers Antonius L J J
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, Research Institute MOVE, University of Amsterdam, and VU University Amsterdam, Van der Boechorststr 7, 1081 BT Amsterdam, The Netherlands.
Odontology. 2009 Jul;97(2):63-75. doi: 10.1007/s10266-009-0101-z. Epub 2009 Jul 29.
Bone has the capacity to regenerate in response to injury. During distraction osteogenesis, the renewal of bone is enhanced by gradual stretching of the soft connective tissues in the gap area between two separated bone segments. This procedure has received much clinical attention as a way to correct congenital growth retardation of bone tissue or to generate bone to fill skeletal defects. The process of bone regeneration involves a complex system of biological changes whereby mechanical stress is converted into a cascade of signals that activate cellular behavior resulting in (enhanced) formation of bone. Over the last decade, significant progress has been made in understanding the bone regeneration process during distraction osteogenesis. The mechanical and biological factors that are important for the success of the distraction treatment have been partially characterized and are discussed in this review.
骨骼具有响应损伤进行再生的能力。在牵张成骨过程中，通过逐渐拉伸两个分离骨段之间间隙区域的软结缔组织，可增强骨的更新。作为一种纠正骨组织先天性生长迟缓或生成骨以填充骨骼缺损的方法，该程序已受到临床的广泛关注。骨再生过程涉及一个复杂的生物变化系统，通过该系统，机械应力被转化为一系列信号，激活细胞行为，从而（增强）形成骨。在过去十年中，在理解牵张成骨过程中的骨再生过程方面取得了重大进展。本文综述了对牵张治疗成功至关重要的机械和生物学因素，并对其进行了部分阐述。
