Prokof'ev V F, Gribacheva I A, Konenkov V I, Ierusalimskiĭ A P
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(11):43-7.
Examination of 166 patients with optic neuritis revealed that 65 of them developed multiple sclerosis (MS) at different times after optic neuritis. The observation period was 9.4 years on the average. Using the clinical, laboratory, immunogenetic methods the clinico-immunogenetic heterogeneity of optic neuritis was discovered, the highly informative specific clinical signs and immunogenetic markers suitable as criteria for predicting different variants of optic neuritis outcomes were defined. Using a heterogeneous successive procedure a method of individual ++pre-nosological prediction of MS in persons with a history of optic neuritis was devised.
对166例视神经炎患者的检查发现，其中65例在视神经炎后的不同时间发展为多发性硬化症（MS）。平均观察期为9.4年。通过临床、实验室、免疫遗传学方法，发现了视神经炎的临床免疫遗传学异质性，确定了作为预测视神经炎不同转归标准的高信息量特异性临床体征和免疫遗传标志物。采用异质性连续程序，设计了一种对视神经炎病史患者进行MS个体++病前预测的方法。
