阿维菌素中毒伴昏迷、肌阵挛和多发性神经病。
Avermectin intoxication with coma, myoclonus, and polyneuropathy.
作者信息
Sung Yueh-Feng, Huang Chuang-Ti, Fan Cheng-Kuo, Lin Chih-Hung, Lin Shiou-Ping
机构信息
Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China.
出版信息
Clin Toxicol (Phila). 2009 Aug;47(7):686-8. doi: 10.1080/15563650903070901.
INTRODUCTION
Avermectin has been used in the control of parasites and insects. Severe poisoning symptoms in humans include altered mental status, hypotension, and respiratory failure.
CASE REPORT
We describe a case of acute avermectin intoxication at a very high dose (414.2 mg/kg) who presented with coma, myoclonus, and polyneuropathy after oral ingestion.
DISCUSSION
The symptoms are supposed to be associated directly with the avermectin poisoning and possibly with the toxicity of solvents or other additives.
CONCLUSION
To the best of our knowledge, this is the first case with avermectin poisoning associated with myoclonus and polyneuropathy in the literature.
引言
阿维菌素已被用于控制寄生虫和昆虫。人类严重中毒症状包括精神状态改变、低血压和呼吸衰竭。
病例报告
我们描述了一例口服摄入极高剂量（414.2毫克/千克）阿维菌素导致急性中毒的病例，患者出现昏迷、肌阵挛和多发性神经病。
讨论
这些症状被认为与阿维菌素中毒直接相关，也可能与溶剂或其他添加剂的毒性有关。
结论
据我们所知，这是文献中首例与肌阵挛和多发性神经病相关的阿维菌素中毒病例。
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