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Administration of Flumazenil in a Patient with Acute Abamectin Intoxication: Case Report and Review of the Literature.氟马西尼用于急性阿维菌素中毒患者的治疗：病例报告及文献复习
West Indian Med J. 2015 Mar;64(2):162-4. doi: 10.7727/wimj.2013.306. Epub 2015 Apr 14.
2
Abamectin intoxication with coma and hypotension.阿维菌素中毒伴昏迷和低血压。
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[Ethanol intoxication treated with flumazenil: a case report].[氟马西尼治疗乙醇中毒：一例报告]
Zhonghua Yi Xue Za Zhi (Taipei). 1991 Dec;48(6):485-8.
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Abamectin as a pesticide for agricultural use.阿维菌素作为一种农用杀虫剂。
Acta Leiden. 1990;59(1-2):217-25.
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Efficacy of flumazenil in acute alcohol intoxication: double blind placebo-controlled evaluation.氟马西尼治疗急性酒精中毒的疗效：双盲安慰剂对照评估。
Hum Exp Toxicol. 1991 Jul;10(4):235-9. doi: 10.1177/096032719101000401.
7
The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep.阿维菌素、莫能菌素和阿维菌素/双羟萘酸噻嘧啶联合用药对感染绵羊的大环内酯类药物耐药的泰乐菌素第 4 期幼虫的比较疗效。
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Hum Exp Toxicol. 2017 Mar;36(3):311-316. doi: 10.1177/0960327116646619. Epub 2016 Jul 11.
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MRI brain findings of Abamectin toxic encephalopathy: a case report with review of literature.阿维菌素中毒性脑病的 MRI 脑表现：一例病例报告并文献复习。
Emerg Radiol. 2023 Dec;30(6):817-821. doi: 10.1007/s10140-023-02180-3. Epub 2023 Nov 10.
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Protective effects of Eruca sativa (rocket) on abamectin insecticide toxicity in male albino rats.芝麻菜对雄性白化大鼠阿维菌素杀虫剂毒性的保护作用。
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Metabolites. 2024 Jun 30;14(7):374. doi: 10.3390/metabo14070374.

本文引用的文献

1
The role of mitochondria and biotransformation in abamectin-induced cytotoxicity in isolated rat hepatocytes.线粒体和生物转化在阿维菌素诱导的离体大鼠肝细胞毒性中的作用。
Toxicol In Vitro. 2013 Mar;27(2):570-9. doi: 10.1016/j.tiv.2012.10.017. Epub 2012 Nov 6.
2
Partial ptosis, dilated pupils and ataxia following abamectin poisoning.
Ceylon Med J. 2012 Sep;57(3):125-6. doi: 10.4038/cmj.v57i3.4706.
3
Acute human toxicity of macrocyclic lactones.大环内酯类药物的急性人体毒性。
Curr Pharm Biotechnol. 2012 May;13(6):999-1003. doi: 10.2174/138920112800399059.
4
Avermectin intoxication with coma, myoclonus, and polyneuropathy.阿维菌素中毒伴昏迷、肌阵挛和多发性神经病。
Clin Toxicol (Phila). 2009 Aug;47(7):686-8. doi: 10.1080/15563650903070901.
5
Abamectin intoxication with coma and hypotension.阿维菌素中毒伴昏迷和低血压。
Clin Toxicol (Phila). 2007;45(3):299-300. doi: 10.1080/15563650601072225.
6
The use of sarmazenil in the treatment of a moxidectin intoxication in a foal.
J Vet Intern Med. 2005 May-Jun;19(3):348-9.
7
The elucidation of epinephrine as an antihypotensive agent in abamectin intoxication.
Hum Exp Toxicol. 2003 Aug;22(8):433-7. doi: 10.1191/0960327103ht378oa.
8
A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate.捻转血矛线虫的一种谷氨酸门控氯离子通道亚基：在哺乳动物细胞系中的表达、配体结合以及谷氨酸对驱虫药结合的调节
Biochem Pharmacol. 2002 Mar 15;63(6):1061-8. doi: 10.1016/s0006-2952(02)00852-3.
9
Abamectin effects on aspartate aminotransferase and nitric oxide in rats.阿维菌素对大鼠天冬氨酸转氨酶和一氧化氮的影响。
Toxicology. 2001 Aug 28;165(2-3):189-93. doi: 10.1016/s0300-483x(01)00434-6.
10
Agricultural avermectins: an uncommon but potentially fatal cause of pesticide poisoning.农用阿维菌素：农药中毒的一种罕见但可能致命的病因。
Ann Emerg Med. 1999 Jul;34(1):51-7. doi: 10.1016/s0196-0644(99)70271-4.

氟马西尼用于急性阿维菌素中毒患者的治疗：病例报告及文献复习

Administration of Flumazenil in a Patient with Acute Abamectin Intoxication: Case Report and Review of the Literature.

作者信息

Sun B, Jia L, Nie S

机构信息

Department of Emergency, Jinling Hospital, Nanjing University, School of Medicine, Nanjing 210002, People's Republic of China.

Department of Emergency, Jinling Hospital, Nanjing University, School of Medicine, 305 East Zhongshan Road, Nanjing City 210002, Jiangsu Province, People's Republic of China.

出版信息

West Indian Med J. 2015 Mar;64(2):162-4. doi: 10.7727/wimj.2013.306. Epub 2015 Apr 14.

DOI:10.7727/wimj.2013.306
PMID:26360693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4696640/
Abstract

Abamectin is used in several countries as a type of macrocyclic lactone insecticide to control nematodes and other pests in livestock and agriculture. This medicine, used for animals and crops, would be highly toxic to human if a person has intentional poisoning. We report a case of a 47-year old man who was admitted to the hospital after ingestion of a large dose of abamectin on purpose, and who rapidly recovered consciousness after administration of flumazenil. Although flumazenil is not the antidote of abamectin, we may hypothesize that it could reduce recovery time and shorten expenditures in hospital. This is the first report that focusses on a specific treatment which could possibly accelerate recovery of consciousness for patients with abamectin intoxication.

摘要

阿维菌素在多个国家被用作一种大环内酯类杀虫剂，用于控制家畜和农业中的线虫及其他害虫。这种用于动物和农作物的药物，如果有人故意中毒，对人类毒性极高。我们报告了一例47岁男性病例，该患者故意大量摄入阿维菌素后入院，在给予氟马西尼后迅速恢复意识。尽管氟马西尼不是阿维菌素的解毒剂，但我们可以推测它可能会缩短恢复时间并减少住院费用。这是第一份聚焦于可能加速阿维菌素中毒患者意识恢复的特定治疗方法的报告。