Department of Pathology and Laboratory Medicine, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada.
Transplant Rev (Orlando). 2009 Oct;23(4):199-208. doi: 10.1016/j.trre.2009.06.005. Epub 2009 Jul 28.
Monocytes/macrophages (MO) have long been recognized to be involved in renal allograft rejection. Monocytes/macrophages have been detected in the glomerular, vascular, and tubulointerstitial compartments during rejection. The recent demonstration that peritubular capillary deposition of complement split factor C4d, a marker for antibody-mediated rejection, is associated with relatively marked MO infiltration of the allograft during acute rejection is a significant development in our understanding of the role of the MO in rejection. High levels of MO in rejecting allografts have been associated with severe rejection, and glomerular MO infiltration in particular has been shown to be an indicator of poor graft outcome.
单核细胞/巨噬细胞（MO）长期以来一直被认为参与了肾移植排斥反应。在排斥反应过程中，单核细胞/巨噬细胞已在肾小球、血管和肾小管间质中被检测到。最近的研究表明，补体分裂因子 C4d 在肾小管周围毛细血管的沉积，是抗体介导排斥反应的标志物，与急性排斥反应期间同种异体移植物中相对明显的 MO 浸润有关，这是我们对 MO 在排斥反应中的作用的理解的一个重要进展。在排斥的同种异体移植物中，MO 水平较高与严重排斥反应有关，特别是肾小球 MO 浸润已被证明是移植物预后不良的指标。
