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T细胞疫苗接种可降低精液中的猿猴免疫缺陷病毒水平。

T-cell vaccination reduces simian immunodeficiency virus levels in semen.

作者信息

Whitney James B, Luedemann Corinne, Hraber Peter, Rao Srinivas S, Mascola John R, Nabel Gary J, Letvin Norman L

机构信息

Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

出版信息

J Virol. 2009 Oct;83(20):10840-3. doi: 10.1128/JVI.01202-09. Epub 2009 Jul 29.

DOI:10.1128/JVI.01202-09
PMID:19640980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2753121/
Abstract

Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

摘要

最近的研究结果表明，大多数人类免疫缺陷病毒1型（HIV-1）的性传播发生在感染的急性期，此时病毒复制最为强烈。在此，我们表明，疫苗引发的细胞免疫反应可在猴子初次感染期间显著降低精液中的猿猴免疫缺陷病毒水平。一种在初次感染期间降低男性精液中HIV-1数量的疫苗可能会减少HIV-1在人群中的传播，从而影响艾滋病的传播。

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T-cell vaccination reduces simian immunodeficiency virus levels in semen.T细胞疫苗接种可降低精液中的猿猴免疫缺陷病毒水平。
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