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急性感染后 SIV 被局限在生殖道。

Genital tract sequestration of SIV following acute infection.

机构信息

Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

出版信息

PLoS Pathog. 2011 Feb;7(2):e1001293. doi: 10.1371/journal.ppat.1001293. Epub 2011 Feb 17.

DOI:10.1371/journal.ppat.1001293
PMID:21379569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3040679/
Abstract

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

摘要

我们通过检测实验性和假疫苗接种恒河猴在原发性感染期间血液和精液相关病毒，来描述雄性生殖道中猴免疫缺陷病毒（SIV）的进化。在病毒复制高峰时，血液和精液中的 SIV 序列混合在一起，支持高水平病毒“溢出”到雄性生殖道的情况。然而，在病毒设定点时，在 7 只评估的猴子中有 4 只出现了分隔现象，这可能是原发性病毒血症消退后，解剖隔室之间病毒基因流动受限的结果。这些发现表明，在病毒血症高峰消退后，SIV 在雄性生殖道中的复制会向分隔演变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8c184e304cfd/ppat.1001293.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/2cb325305fac/ppat.1001293.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8cfd0316faaf/ppat.1001293.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/53fcc757e630/ppat.1001293.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/da41b320f8ef/ppat.1001293.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/6d20679fb1c6/ppat.1001293.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8579e8c3c318/ppat.1001293.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8c184e304cfd/ppat.1001293.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/2cb325305fac/ppat.1001293.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8cfd0316faaf/ppat.1001293.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/53fcc757e630/ppat.1001293.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/da41b320f8ef/ppat.1001293.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/6d20679fb1c6/ppat.1001293.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8579e8c3c318/ppat.1001293.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edac/3040679/8c184e304cfd/ppat.1001293.g007.jpg

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