Steger R W, Murphy L L, Bartke A, Smith M S
Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901-6512.
Pharmacol Biochem Behav. 1990 Oct;37(2):299-302. doi: 10.1016/0091-3057(90)90338-i.
The acute dose-response effects of delta-9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) on gonadotropin and testosterone (T) secretion and on hypothalamic norepinephrine (NE) metabolism were tested in adult male rats. THC and CBN both produced an acute suppression of plasma-luteinizing hormone (LH) and T levels and median eminence NE turnover although a dose-response relationship could not be demonstrated. CBD had no significant effect on any of these parameters and none of these cannabinoids had any effect on plasma follicle-stimulating hormone levels or median eminence LH-releasing hormone (LHRH) content. Except for the highest dose of CBN, none of the in vivo cannabinoid treatments significantly altered in vitro LH secretion although there was a trend towards decreased LH secretion. These results suggest that the decrease in LH secretion in THC- or CBN-treated rats is due to reductions in NE stimulation of LHRH release rather than to changes in LHRH synthesis or pituitary LHRH response.
在成年雄性大鼠中测试了δ-9-四氢大麻酚（THC）、大麻酚（CBN）和大麻二酚（CBD）对促性腺激素和睾酮（T）分泌以及下丘脑去甲肾上腺素（NE）代谢的急性剂量反应效应。THC和CBN均能急性抑制血浆促黄体生成素（LH）和T水平以及正中隆起NE周转率，尽管未能证明其剂量反应关系。CBD对这些参数均无显著影响，且这些大麻素均对血浆促卵泡生成素水平或正中隆起促黄体生成素释放激素（LHRH）含量无任何影响。除最高剂量的CBN外，尽管存在LH分泌减少的趋势，但体内大麻素处理均未显著改变体外LH分泌。这些结果表明，THC或CBN处理大鼠中LH分泌的减少是由于NE对LHRH释放的刺激减少，而非LHRH合成或垂体LHRH反应的改变。
