大麻二酚可减弱大麻酚的δ9 - 四氢大麻酚样辨别刺激效应。
Cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol.
作者信息
Hiltunen A J, Järbe T U
出版信息
Eur J Pharmacol. 1986 Jun 17;125(2):301-4. doi: 10.1016/0014-2999(86)90042-7.
PMID:3017729
Abstract
Interaction effects of cannabidiol (CBD) and cannabinol (CBN) were examined using a drug discrimination procedure in which rats had been trained to discriminate between 3 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) and vehicle (2 ml/kg). The generalization effects of CBN to delta 9-THC were attenuated when CBN was administered together with CBD. The results were time- and dose-dependent.
摘要
使用药物辨别程序研究了大麻二酚（CBD）和大麻酚（CBN）的相互作用，在该程序中，大鼠已被训练以区分3mg/kg的δ9-四氢大麻酚（δ9-THC）和赋形剂（2ml/kg）。当CBN与CBD一起给药时，CBN对δ9-THC的泛化作用减弱。结果具有时间和剂量依赖性。
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