Wu Xiao-Bing, Dai Li-Ping, Wang Yan-Ping, Wang Kai-Juan, Zhang Jian-Ying
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Mar;30(3):281-5.
To explore the association between XPD codon 751 polymorphism and esophageal cancer (EC) by systematically reviewing the risk of the original studies.
A comprehensive search was conducted to identify all case-control studies of XPD codon 751 polymorphism and EC risk. Meta-analysis was applied with Rev Man 4.2 software for calculation of pooled OR value (with 95% CI) of EC, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).
Of the 12 case-control studies selected for this Meta-analysis, a total of 2558 EC cases and 5122 controls were included. Compared with the wild-type homozygote Lys/Lys, the pooled Odds Ratios (with 95% CI) of Lys/Gln, Gln/Gln, (Lys/Gln + Gln/Gln) genotypes of XPD codon 751 polymorphism for EC risk were 1.19 (1.05, 1.34), 1.22 (0.86, 1.74), 1.20 (1.01, 1.42), respectively. In a stratified analysis, a total of 1417 ESCC cases and 2312 controls were included, and individuals carrying Lys/Gln genotype or (Lys/Gln + Gln/Gln) had 1.22-fold or 1.24-fold excess risks for ESCC compared with those carrying Lys/Lys genotype. A total of 935 EAC cases and 2604 controls were included, and none of the genotype of XPD codon 751 genetic polymorphism was found to be related to EAC.
Both heterozygote Lys/Gln and (Lys/Gln + Gln/Gln) for XPD codon 751 genetic polymorphism were associated with an increased risk of developing esophageal cancer. Furthermore, heterozygote Lys/Gln and (Lys/Gln + Gln/Gln) for XPD codon 751 genetic polymorphism might have increased the risk of ESCC, but have no association with EAC.
通过系统评价原始研究的风险，探讨XPD基因第751位密码子多态性与食管癌（EC）之间的关联。
进行全面检索以确定所有关于XPD基因第751位密码子多态性与EC风险的病例对照研究。应用Rev Man 4.2软件进行荟萃分析，计算EC、食管鳞状细胞癌（ESCC）和食管腺癌（EAC）的合并比值比（OR值）及其95%置信区间（CI）。
本荟萃分析纳入的12项病例对照研究共包括2558例EC病例和5122例对照。与野生型纯合子Lys/Lys相比，XPD基因第751位密码子多态性的Lys/Gln、Gln/Gln、（Lys/Gln + Gln/Gln）基因型发生EC的合并比值比（95%CI）分别为1.19（1.05，1.34）、1.22（0.86，1.74）、1.20（1.01，1.42）。分层分析中，共纳入1417例ESCC病例和2312例对照，携带Lys/Gln基因型或（Lys/Gln + Gln/Gln）基因型的个体发生ESCC的风险比携带Lys/Lys基因型的个体高1.22倍或1.24倍。共纳入935例EAC病例和2604例对照，未发现XPD基因第751位密码子基因多态性的任何基因型与EAC有关。
XPD基因第751位密码子基因多态性的杂合子Lys/Gln和（Lys/Gln + Gln/Gln）均与食管癌发生风险增加有关。此外，XPD基因第751位密码子基因多态性的杂合子Lys/Gln和（Lys/Gln + Gln/Gln）可能增加了ESCC的发生风险，但与EAC无关。
