一种与智力/发育障碍成人问题行为相关的单胺氧化酶A启动子基因。
Monoamine oxidase a promoter gene associated with problem behavior in adults with intellectual/developmental disabilities.
作者信息
May Michael E, Srour Ali, Hedges Lora K, Lightfoot David A, Phillips John A, Blakely Randy D, Kennedy Craig H
机构信息
Southern Illinois University, Illinois, USA.
出版信息
Am J Intellect Dev Disabil. 2009 Jul;114(4):269-73. doi: 10.1352/1944-7558-114.4.269-273.
A functional polymorphism in the promoter of the gene encoding monoamine oxidase A has been associated with problem behavior in various populations. We examined the association of MAOA alleles in adult males with intellectual/developmental disabilities with and without established histories of problem behavior. These data were compared with a gender, ethnicity, and age-matched contrast sample. About 43% (15/35) of adults with intellectual/developmental disabilities and problem behavior possessed the low-efficiency version of the MAOA gene. In comparison, 20% (7/35) of adults with intellectual/developmental disabilities and no problem behavior and 20% (7/35) of the contrast group had the short-allele MAOA polymorphism. Therefore, a common variant in the MAOA gene may be associated with problem behavior in adults with intellectual/developmental disabilities.
编码单胺氧化酶A的基因启动子中的功能性多态性已与不同人群的问题行为相关联。我们研究了成年男性智力/发育障碍患者中MAOA等位基因与有无问题行为既往史之间的关联。这些数据与性别、种族和年龄匹配的对照样本进行了比较。约43%（15/35）有智力/发育障碍且有问题行为的成年人携带低效率版本的MAOA基因。相比之下，有智力/发育障碍但无问题行为的成年人中20%（7/35）以及对照组中20%（7/35）有MAOA基因短等位基因多态性。因此，MAOA基因中的一个常见变体可能与有智力/发育障碍的成年人的问题行为有关。
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