Marques Ilza Lazarini, Monteiro Luiz Carlos Silveira, de Souza Luiz, Bettiol Heloísa, Sassaki Catarina Hissako, de Assumpção Costa Renise
Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru, Brazil.
Cleft Palate Craniofac J. 2009 Jul;46(4):448-53. doi: 10.1597/08-120.1. Epub 2008 Nov 12.
To study the prevalence of abnormal gastroesophageal reflux in infants with Robin sequence who had severe respiratory obstruction treated with nasopharyngeal intubation and to evaluate the efficacy of nonsurgical treatment.
Longitudinal prospective study.
Hospital de Reabilitação de Anomalias Craniofaciais, University of São Paulo, Brazil.
Twenty infants with severe isolated Robin sequence treated with nasopharyngeal intubation.
We performed 24-hour esophageal pH monitoring on each child at 2, 4, and 6 months of age. Respiratory and feeding status were evaluated. We considered abnormal gastroesophageal reflux as reflux index values above the 95th percentile of the Vandenplas reference for normal children.
The prevalence of reflux index above the 95th percentile at the first exam was 6/20, a value significantly higher than the reference (5/103, p < .01). At the second and third exams, reflux index values were decreased. Ninety percent of the infants showed improvement of respiratory difficulty and developed oral feeding capacity.
The prevalence of abnormal gastroesophageal reflux is higher in infants with severe cases of Robin sequence than in normal infants. Nonsurgical procedures improved respiratory and feeding difficulties of most of these infants.
研究接受鼻咽插管治疗的患有罗宾序列征且有严重呼吸阻塞的婴儿中胃食管反流异常的患病率，并评估非手术治疗的疗效。
纵向前瞻性研究。
巴西圣保罗大学颅面畸形康复医院。
20例接受鼻咽插管治疗的严重孤立性罗宾序列征婴儿。
在每个儿童2、4和6个月大时进行24小时食管pH监测。评估呼吸和喂养状况。我们将胃食管反流异常定义为反流指数值高于正常儿童范登普拉斯参考值的第95百分位数。
首次检查时反流指数高于第95百分位数的患病率为6/20，该值显著高于参考值（5/103，p <.01）。在第二次和第三次检查时，反流指数值下降。90%的婴儿呼吸困难得到改善，并发展出经口喂养能力。
严重罗宾序列征婴儿中胃食管反流异常的患病率高于正常婴儿。非手术治疗改善了这些婴儿中大多数的呼吸和喂养困难。
