辛伐他汀抑制人子宫内膜间质细胞的增殖和收缩性：治疗子宫内膜异位症的有前途的药物。
Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.
出版信息
Fertil Steril. 2009 Dec;92(6):2097-9. doi: 10.1016/j.fertnstert.2009.06.055. Epub 2009 Jul 30.
Abstract
Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis.
摘要
辛伐他汀显著抑制了子宫内膜间质细胞的增殖，减弱了这些细胞介导的胶原凝胶收缩，并抑制了子宫内膜间质细胞附着在胶原纤维上。辛伐他汀被认为是一种有前途的治疗子宫内膜异位症相关纤维化的药物，而子宫内膜异位症相关纤维化是子宫内膜异位症引起的主要病变之一。
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