Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, PR China.
Eur J Cancer. 2009 Dec;45(18):3303-14. doi: 10.1016/j.ejca.2009.06.029. Epub 2009 Jul 28.
Colorectal cancer is the third most common form of cancer and the fourth most frequent cause of cancer deaths worldwide. Its development is influenced by both environmental and genetic factors. The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs). However, epidemiologic findings have been inconsistent. To investigate a putative association of GSTP1 Ile105Val polymorphism with the risk of colorectal cancer, we performed a meta-analysis and HuGE review of 16 published case-control studies (involving a total of 4386 colorectal cancer patients and 7127 controls). We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, the comparison of Val versus Ile allele showed no differential susceptibility to colorectal cancer (OR=0.98, 95% CI: 0.92-1.04). A protective effect was found in recessive, with an OR of 0.86 (95% CI: 0.76-0.98). Whereas no significant association was observed in either dominant or codominant model. In stratified subgroup analysis, no effect of Val allele was seen in subjects of Caucasian and Asian descent, and in healthy and hospital controls. In conclusion, the meta-analysis suggests that the GSTP1 Ile105Val polymorphism is unlikely to increase considerably the risk of sporadic colorectal cancer, and it should be confirmed in further studies.
结直肠癌是全球第三大常见癌症和第四大癌症死亡原因。它的发展受到环境和遗传因素的影响。谷胱甘肽 S-转移酶 P1 基因（GSTP1）是结直肠癌易感性的一个特别有吸引力的候选基因，因为它编码参与环境致癌物如多环芳烃（PAHs）代谢的酶。然而，流行病学研究结果并不一致。为了研究 GSTP1 Ile105Val 多态性与结直肠癌风险之间的可能关联，我们对 16 项已发表的病例对照研究（共涉及 4386 名结直肠癌患者和 7127 名对照）进行了荟萃分析和 HuGE 综述。我们使用比值比（ORs）及其 95%置信区间（CIs）来评估关联的强度。总体而言，Val 与 Ile 等位基因的比较显示对结直肠癌没有不同的易感性（OR=0.98，95%CI：0.92-1.04）。在隐性遗传中发现了保护作用，OR 为 0.86（95%CI：0.76-0.98）。而在显性或共显性模型中没有观察到显著的关联。在分层亚组分析中，在白人和亚洲血统的受试者、健康和医院对照中，Val 等位基因没有影响。总之，荟萃分析表明 GSTP1 Ile105Val 多态性不太可能显著增加散发性结直肠癌的风险，需要在进一步的研究中得到证实。
