Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Tianjin 300192, People's Republic of China.
Department of Thyroid and Breast Surgery, Tianjin 4th Center Hospital, Tianjin 300140, People's Republic of China.
Biosci Rep. 2019 Jan 25;39(1). doi: 10.1042/BSR20181226. Print 2019 Jan 31.
We observed inconsistent conclusions regarding the genetic role of glutathione S-transferase gene polymorphisms, including glutathione S-transferase M1 (), glutathione S-transferase T1 () present/null, and glutathione S-transferase pi ) Ile105Val polymorphisms, in the susceptibility to nasal or colorectal polyposis (NP or CP). Thus, we aimed to perform a meta-analysis to comprehensively evaluate this association by applying Stata/SE software. After the heterogeneity assumption, Mantel-Haenszel statistics were used to obtain the odds ratio (OR), 95% confidence interval (95% CI) and -value of the association test ( ). We obtained a total of 235 articles by searching online databases. After screening, ten eligible case-control studies were finally enrolled in our meta-analysis. For the meta-analysis of the gene under present versus null, we observed a decreased risk of NP [OR = 0.65; =0.018], but not CP. In addition, we did not detect any evident association between the present/null polymorphism and NP or CP risk. For the meta-analysis of the Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; =0.027), Ile/Val versus Ile/Ile (OR = 1.70; =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; =0.010). In conclusion, the null genotype of the polymorphism may be linked to an increased susceptibility to NP, whereas the Ile/Val genotype of the Ile105Val polymorphism may be associated with a decreased risk of NP.
我们观察到谷胱甘肽 S-转移酶基因多态性（包括谷胱甘肽 S-转移酶 M1()、谷胱甘肽 S-转移酶 T1() 存在/缺失和谷胱甘肽 S-转移酶 pi()Ile105Val 多态性）在鼻息肉或结直肠息肉（NP 或 CP）易感性中的遗传作用的结论不一致。因此，我们旨在通过应用 Stata/SE 软件进行荟萃分析来全面评估这种关联。在异质性假设之后，使用 Mantel-Haenszel 统计量获得关联检验的优势比（OR）、95%置信区间（95%CI）和-值（）。通过在线数据库搜索，我们共获得 235 篇文章。经过筛选，最终有 10 项符合条件的病例对照研究纳入我们的荟萃分析。对于 基因的存在/缺失的荟萃分析，我们观察到 NP 的风险降低[OR=0.65；=0.018]，但 CP 没有。此外，我们没有发现 基因的存在/缺失多态性与 NP 或 CP 风险之间存在任何明显关联。对于 Ile105Val 多态性的荟萃分析，与对照组相比，Val 与 Ile 相比（OR=1.36；=0.027）、Ile/Val 与 Ile/Ile 相比（OR=1.70；=0.011）和 Ile/Val+Val/Val 与 Ile/Ile 相比（OR=1.65；=0.010），NP 病例的风险增加。总之， 基因的缺失基因型可能与 NP 的易感性增加有关，而 基因的 Ile105Val 多态性的 Ile/Val 基因型可能与 NP 的风险降低有关。
