淋巴因子对人外周血单个核细胞β-肾上腺素能受体刺激的影响。

Effect of lymphokines on beta-adrenoceptor stimulation of human PBMC.

作者信息

Van Oosterhout A J, Stam W B, Nijkamp F P

机构信息

Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.

出版信息

Agents Actions Suppl. 1990;31:163-7. doi: 10.1007/978-3-0348-7379-6_21.

DOI:10.1007/978-3-0348-7379-6_21

Abstract

The effect of IL-2, IL-3, IL-4 and GM-CSF on beta-adrenoceptor function of human peripheral blood mononuclear cells (PBMC) was studied. After a 2 h pre-incubation period of PBMC with each of the lymphokines (1-100 units/ml), the isoprenaline stimulated cAMP production in these cells was not altered. However, IL-2 and GM-CSF induced a concentration dependent decrease of the beta-adrenoceptor agonist stimulated cAMP production after a 20 h pre-incubation period.

摘要

研究了白细胞介素-2（IL-2）、白细胞介素-3（IL-3）、白细胞介素-4（IL-4）和粒细胞巨噬细胞集落刺激因子（GM-CSF）对人外周血单个核细胞（PBMC）β-肾上腺素能受体功能的影响。在PBMC与每种淋巴因子（1-100单位/毫升）预孵育2小时后，异丙肾上腺素刺激这些细胞中cAMP的产生没有改变。然而，在预孵育20小时后，IL-2和GM-CSF诱导β-肾上腺素能受体激动剂刺激的cAMP产生呈浓度依赖性下降。

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