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1
Effect of lymphokines on beta-adrenoceptor function of human peripheral blood mononuclear cells.淋巴因子对人外周血单个核细胞β-肾上腺素能受体功能的影响。
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):150S-152S. doi: 10.1111/j.1365-2125.1990.tb05490.x.
2
Effect of lymphokines on beta-adrenoceptor stimulation of human PBMC.淋巴因子对人外周血单个核细胞β-肾上腺素能受体刺激的影响。
Agents Actions Suppl. 1990;31:163-7. doi: 10.1007/978-3-0348-7379-6_21.
3
Effects of cytokines on beta-adrenoceptor function of human peripheral blood mononuclear cells and guinea pig trachea.细胞因子对人外周血单个核细胞及豚鼠气管β-肾上腺素能受体功能的影响
J Allergy Clin Immunol. 1992 Sep;90(3 Pt 1):340-8. doi: 10.1016/s0091-6749(05)80013-2.
4
Effect of human interleukin-2 from different sources on lymphocyte and airway beta-adrenoceptor function.不同来源的人白细胞介素-2对淋巴细胞及气道β-肾上腺素能受体功能的影响
Int J Immunopharmacol. 1990;12(4):409-12. doi: 10.1016/0192-0561(90)90023-g.
5
Activities of granulocyte-macrophage colony-stimulating factor and interleukin-3 on monocytes.粒细胞巨噬细胞集落刺激因子和白细胞介素-3对单核细胞的作用。
Am J Hematol. 2004 Apr;75(4):179-89. doi: 10.1002/ajh.20010.
6
Regulatory effects of T cell lymphokines on cytokine gene expression in monocytes.T细胞淋巴因子对单核细胞中细胞因子基因表达的调节作用。
Lymphokine Cytokine Res. 1993 Dec;12(6):457-64.
7
Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype.β-肾上腺素能受体介导的对活化的人T淋巴细胞中IFN-γ、IL-3和GM-CSF mRNA积累的抑制作用仅由β2-肾上腺素能受体亚型介导。
Am J Respir Cell Mol Biol. 1998 Sep;19(3):400-7. doi: 10.1165/ajrcmb.19.3.2765.
8
Comparative effect of recombinant IL-1, -2, -3, -4, and -6, IFN-gamma, granulocyte-macrophage-colony-stimulating factor, tumor necrosis factor-alpha, and histamine-releasing factors on the secretion of histamine from basophils.重组白细胞介素-1、-2、-3、-4、-6、干扰素-γ、粒细胞-巨噬细胞集落刺激因子、肿瘤坏死因子-α及组胺释放因子对嗜碱性粒细胞组胺分泌的比较作用
J Immunol. 1989 May 15;142(10):3431-5.
9
Recombinant interleukin 3 induces interleukin 2 receptor expression on early myeloid cells in normal human bone marrow.重组白细胞介素3可诱导正常人骨髓早期髓样细胞上白细胞介素2受体的表达。
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Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor and interleukin 4 induce differentiation in the U-937 human monocytic leukemia cell line.粒细胞集落刺激因子、粒细胞巨噬细胞集落刺激因子和白细胞介素4可诱导人单核细胞白血病U-937细胞系分化。
Leuk Lymphoma. 1996 Jun;22(1-2):163-71,follow.186,color plate XIV-V. doi: 10.3109/10428199609051744.

本文引用的文献

1
Inhibition of adenylate cyclase by IL 2 in human T lymphocytes is mediated by protein kinase C.白细胞介素2对人T淋巴细胞中腺苷酸环化酶的抑制作用是由蛋白激酶C介导的。
Biochem Biophys Res Commun. 1987 May 29;145(1):176-82. doi: 10.1016/0006-291x(87)91303-9.
2
Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines.白细胞介素2受体在肺结节病期间由肺泡巨噬细胞表达，并且可通过对正常人肺巨噬细胞、血液单核细胞和单核细胞系进行淋巴因子处理来诱导表达。
J Immunol. 1987 Jan 1;138(1):185-91.
3
Beta-adrenoceptor function in asthmatic bronchial smooth muscle.哮喘患者支气管平滑肌中的β-肾上腺素能受体功能
Gen Pharmacol. 1988;19(3):307-11. doi: 10.1016/0306-3623(88)90021-3.
4
Stimulation of guanylate cyclase activity and reduction of adenylate cyclase activity by granulocyte-macrophage colony-stimulating factor in human blood neutrophils.粒细胞-巨噬细胞集落刺激因子对人血中性粒细胞中鸟苷酸环化酶活性的刺激及腺苷酸环化酶活性的降低
J Immunol. 1988 Apr 15;140(8):2695-701.
5
Disturbed adrenergic regulation of coronary flow in the guinea-pig heart after endotoxin.内毒素作用后豚鼠心脏冠状动脉血流的肾上腺素能调节紊乱。
Eur J Pharmacol. 1985 Dec 3;118(3):341-5. doi: 10.1016/0014-2999(85)90145-1.
6
Cyclosporin-A prevents endotoxin-induced beta-adrenoceptor impairment in lymphocytes.环孢素A可预防内毒素诱导的淋巴细胞β-肾上腺素能受体损伤。
Eur J Pharmacol. 1988 Apr 27;149(1-2):191-2. doi: 10.1016/0014-2999(88)90063-5.
7
Involvement of the spleen in the endotoxin-induced deterioration of the respiratory airway and lymphocyte beta-adrenergic systems of the guinea pig.脾脏参与内毒素诱导的豚鼠呼吸道和淋巴细胞β-肾上腺素能系统的恶化。
Eur J Pharmacol. 1988 Mar 15;147(3):421-9. doi: 10.1016/0014-2999(88)90177-x.
8
Decreased arterial responsiveness to multiple cyclic AMP-generating receptor agonists in spontaneously hypertensive rats.自发性高血压大鼠对多种环磷酸腺苷生成受体激动剂的动脉反应性降低。
Br J Pharmacol. 1989 Jan;96(1):227-35. doi: 10.1111/j.1476-5381.1989.tb11804.x.
9
Alpha- and beta-adrenoceptors in hypertension. II. Platelet alpha 2- and lymphocyte beta 2-adrenoceptors in children of parents with essential hypertension. A model for the pathogenesis of the genetically determined hypertension.高血压中的α和β肾上腺素能受体。II. 原发性高血压患者子女的血小板α2和淋巴细胞β2肾上腺素能受体。遗传决定型高血压发病机制的一个模型
J Cardiovasc Pharmacol. 1989 Mar;13(3):432-9. doi: 10.1097/00005344-198903000-00011.

淋巴因子对人外周血单个核细胞β-肾上腺素能受体功能的影响。

Effect of lymphokines on beta-adrenoceptor function of human peripheral blood mononuclear cells.

作者信息

van Oosterhout A J, Nijkamp F P

机构信息

Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.

出版信息

Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):150S-152S. doi: 10.1111/j.1365-2125.1990.tb05490.x.

DOI:10.1111/j.1365-2125.1990.tb05490.x
PMID:2176522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1368120/
Abstract

Pathological induced changes in beta-adrenoceptor function occur in diseases such as asthma and hypertension. The mechanism(s) of this dysfunction is at present unclear. In the present study, the effect of lymphokines on beta-adrenoceptor agonist induced cAMP production in peripheral blood mononuclear cells (PBMC) is investigated. Pre-incubation of PBMC during 20 h with interleukin-2 (IL-2, 100 u ml-1) and granulocyte/macrophage-colony stimulating factor (GM-CSF, 100 u ml-1) significantly decreases beta-adrenoceptor agonist induced cAMP production by 35 +/- 8% and 37 +/- 11% respectively. IL-3 and IL-4 do not affect beta-adrenoceptor agonist induced cAMP production in PBMC. It can be concluded that IL-2 and GM-CSF, mediators derived from T-lymphocytes, can induce beta-adrenoceptor dysfunction in PBMC.

摘要

在诸如哮喘和高血压等疾病中会出现病理性诱导的β-肾上腺素能受体功能变化。目前这种功能障碍的机制尚不清楚。在本研究中，研究了淋巴因子对外周血单核细胞（PBMC）中β-肾上腺素能受体激动剂诱导的环磷酸腺苷（cAMP）产生的影响。将PBMC与白细胞介素-2（IL-2，100 U/ml）和粒细胞/巨噬细胞集落刺激因子（GM-CSF，100 U/ml）预孵育20小时，可使β-肾上腺素能受体激动剂诱导的cAMP产生分别显著降低35±8%和37±11%。IL-3和IL-4不影响PBMC中β-肾上腺素能受体激动剂诱导的cAMP产生。可以得出结论，源自T淋巴细胞的介质IL-2和GM-CSF可诱导PBMC中的β-肾上腺素能受体功能障碍。