Becker Nils B, Everaers Ralf
Centre Blaise Pascal et Laboratoire de Physique, CNRS UMR 5672, Ecole Normale Supérieure, Université de Lyon, 46 Allée d'Italie, 69007 Lyon, France.
Science. 2009 Jul 31;325(5940):538; author reply 538. doi: 10.1126/science.1168786.
Mathew-Fenn et al. (Reports, 17 October 2008, p. 446) reported unexpected distance fluctuations in short end-labeled DNA constructs and interpreted them as evidence for cooperative DNA stretching modes. We show that when accounting for a subtle linker leverage effect, their data can be understood within standard noncooperative DNA elasticity.
马修 - 芬恩等人(《报告》,2008年10月17日,第446页)报道了短末端标记DNA构建体中意外的距离波动,并将其解释为协同DNA拉伸模式的证据。我们表明,当考虑到微妙的连接体杠杆效应时,他们的数据可以在标准的非协同DNA弹性范围内得到理解。