Wang William Wei Jun, Xia Cai Wei, Zhu Feng, Zhu Ze Zhang, Wang Bin, Wang Shou Feng, Yeung Benson Hiu Yan, Lee Simon Kwong Man, Cheng Jack Chun Yiu, Qiu Yong
Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Spine (Phila Pa 1976). 2009 Aug 1;34(17):1849-54. doi: 10.1097/BRS.0b013e3181ab358c.
A correlation analysis between histologic grade (HG) of iliac crest apophysis and skeletal age assessments.
To study the correlation between HGs of iliac crest apophysis and the skeletal age of hand and wrist, digital skeletal age (DSA), and Risser sign in the girls with adolescent idiopathic scoliosis (AIS).
The evaluation of the remaining growth of the patients clinically and radiologically is highly significant in predicting the curve progression and thus influencing the treatment strategy in AIS.
Fifty-three AIS girls with a mean age of 14.0 years undergoing corrective posterior spinal surgery and instrumentation with autogenous bone graft were recruited. Menarche status was recorded while the skeletal age of hand and wrist, DSA, and Risser grade were evaluated radiologically. Using a standardized HG of proliferative chondrocyte zone of the iliac crest apophysis, correlation between the HGs and the radiologic and clinical skeletal maturity parameters was analyzed.
The HGs were negatively correlated with the radiologic parameters with the highest correlation coefficient between HGs and skeletal age of hand and wrist. The negative correlation between HGs and the 2 clinical parameters was significant and could be enhanced by combining with the radiologic parameters. No proliferative chondrocyte zone of the apophysis was detected when patients were either over 16 years of skeletal age or Risser grade 5, as well as 2-year postmenarche or over 15 years of chronological age in patients with DSA stage III and Risser grade 4.
Radiologic skeletal age of the wrist and digits can provide important information for maturity assessment in girls with AIS. It can also enhance the sensitivity of clinical parameters in determining the remaining growth potential.
髂嵴骨骺组织学分级（HG）与骨骼年龄评估之间的相关性分析。
研究青少年特发性脊柱侧凸（AIS）女孩中髂嵴骨骺的HG与手和腕部骨骼年龄、数字骨骼年龄（DSA）以及Risser征之间的相关性。
对患者剩余生长情况进行临床和放射学评估对于预测侧弯进展并进而影响AIS的治疗策略具有重要意义。
招募了53名平均年龄为14.0岁、接受后路脊柱矫正手术及自体骨移植内固定的AIS女孩。记录月经初潮状态，同时对手和腕部骨骼年龄、DSA以及Risser分级进行放射学评估。使用标准化的髂嵴骨骺增殖软骨细胞区HG，分析HG与放射学及临床骨骼成熟度参数之间的相关性。
HG与放射学参数呈负相关，其中HG与手和腕部骨骼年龄之间的相关系数最高。HG与两个临床参数之间的负相关显著，并且通过与放射学参数相结合可增强这种相关性。当患者骨骼年龄超过16岁或Risser分级为5级，以及DSA III期且Risser分级为4级的患者月经初潮后2年或实际年龄超过15岁时，未检测到骨骺的增殖软骨细胞区。
腕部和手指的放射学骨骼年龄可为AIS女孩的成熟度评估提供重要信息。它还可以提高临床参数在确定剩余生长潜力方面的敏感性。
